Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.
نویسندگان
چکیده
A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2011